江苏省-南通市-启东市 | 若干人
Responsibilities:
• Direct responsibility for the design and execution of experimental in vivo and/or ex vivo/in vitro strategies, closely overseeing the generation, analysis, interpret data.
• Perform and be in charge of complex in vivo pharmacology experiments utilizing tumor models (syngeneic, xenograft tumor models and humanized mouse models) in both immunocompetent and immunocompromised mice; responsible for project execution, data update/presentation, and study report preparation.
• Hands on in vivo skills: perform formulation and conduct animal dosing (IV, PO, IP, SC), tumor implantation, blood/tissue collection, surgery, etc.
• Perform and be in charge of complex in vitro pharmacology experiments in cell culture, passaging and harvesting cells. Executing in vitro/ex vivo assays, such as qPCR, ELISA (MSD), WB etc.
• Accurately interpret experimental data, draw general conclusions, and effectively communicate data with internal colleagues and external clients, capable of presenting scientific results to team members or to a multidisciplinary team of researchers.
• Lead trouble-shooting and issue solving efforts to ensure successful delivery of client’s projects
• Mentor/train junior scientists and colleagues on best practices in the laboratory.
• Implement, optimize, and validate novel in vitro/in vivo models. Routinely generates new ideas, systematically evaluates new technologies and implements those that add value.
Qualifications:
• PhD in Oncology, Pharmacology, Immunology, Immuno-oncology, Molecular/Cell Biology, or associated field, a strong background in in vivo biology, pharmaceutical industry experience with emphasis on oncology and immuno-oncology work is preferred.
• Track record of leveraging in vitro/in vivo pharmacology to explore cancer biology and enable cancer drug discovery is a plus. Demonstrated good experimental design, in-depth data analysis and interpretation on strong scientific rationale and understanding of pharmacological concepts (efficacy, PK/PD relationships).
• Experience with ancillary in vitro and ex vivo assays to characterize effects of experimental medicines (multi-color flow cytometry, T cell/B cell cultures, cytokine/inflammatory mediator assessment, and understanding of immunological readouts and their translational significance is a major plus.
• Highly motivated interactive, creative and ability to work in a fast-paced dynamic team environment and be flexible in case of changing priorities.
• Excellent leadership skills, communication skills, both written and verbal, with strong interpersonal skills, effectively collaborate with internal and external colleagues and clients across a highly matrixed environment to drive decisional experimentation is expected that add value.