江苏省-苏州市 | 1人
Role
We are currently seeking an experienced scientist to join our growing protein crystallography team based in Suzhou, China. In close collaboration with the various groups of Protein Science Platform at WuXi AppTec, we work on structural biology projects covering a wide variety of target classes to support our clients’ diverse research projects. Your main responsibilities will include the characterization and crystallization of protein-ligand complexes of both established and new targets, developing strategies for the optimization of protein crystals and performing data collection and structure determination. You will interact closely both with the protein purification and biophysics groups in Suzhou, Shanghai and Munich, Germany.
Responsibilities
• To solve protein structures using X-ray crystallography technique to inform the interaction mode of compounds
• To help guide the production of suitable protein for structural studies by working closely with Protein Science colleagues
• Facilitate internal collaborations to address issues related to accessing certain protein families for structural work
• Effectively coordinate and communicate timely results through presentations, e-mails and reports
Required skills
• PhD in a structural biology with 5-7 years of postdoctoral/industrial experience in small molecule drug discovery
• Hands-on experience and demonstrated success of protein crystallization, optimization, data collection and crystal structure determination
• Familiar with state-of-the-art liquid handling robotics in protein crystallization as well as mounting of protein crystals and collecting x-ray diffraction data on in-house or synchrotron radiation sources
• Strong knowledge and understanding of biophysical methods, such as SPR and DSC/DSF
• Attention to detail, excellent troubleshooting and problem-solving skills, ability to work in a multidisciplinary, fast-paced, goal-oriented team
• Responsible as project technical lead on multiple projects, with responsibility for project outcome and customer interaction, including developing customer relationship to grow the business Desirable skills & Experiences
• Experience with the crystallization of membrane proteins is a plus
• Experience with multiple hit ID, fragment-based technologies, and assays for in vitro campaigns is preferred
• Use of molecular biology and structure prediction analysis software
• Basic chemistry knowledge in the area of protein-ligand interactions